PUBLICATIONS

Springer J, Azer J, Hua R, Adamczyk A, Robbins C, McBoyle S, Bissell MB, Rose RA. The natriuretic peptides BNP and CNP increase heart rate and electrical conduction by stimulating ionic currents in the sinoatrial node and atrial myocardium following activation of guanylyl cyclase-linked natriuretic peptide receptors. J Mol Cell Cardiol 2012;52:1122-1134.

Azer J, Vella K, Hua R, Rose RA. Natriuretic peptides regulate heart rate and sinoatrial node function by activating multiple natriuretic peptide receptors. J Mol Cell Cardiol 2012;53:715-724.

Hua R, Adamczyk A, Robbins C, Ray G, Rose RA. Distinct patterns of constitutive phosphodiesterase activity in mouse sinoatrial node and atrial myocardium. PLoS One 2012;7:e47652.

Rose RA, Belke DD, Maleckar, MM, Giles WR. Ca2+ entry through TRP channels regulates fibroblast biology in chronic atrial fibrillation. Circulation 2012;126:2039.

Zhang S, Kim KH, Rosen A, Smyth JW, Sakukma R, Delgado-Olguin P, Davis M, Chi NC, Puviindran V, Gaborit N, Sukonnik T, Wylie JN, Brand-Arzamendi K, Farman G, Kim J, Rose RA, Marsden PA, Zhu Y, Zhou YQ, Miquerol L, Henkelman RM, Stainier DYR, Shaw RM, Hui CC, Bruneau BG, Backx PH. Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network. Proc Nat Acad Sci USA 2011;108:13576-13581.

Rose RA, Sellan M, Simpson JA, Izaddoustdar, F, Cifelli C, Panama BK, Davis M, Zhao D, Markhani M, Murphy GG, Striessnig J, Liu PP, Heximer SP, Backx PH. Iron-overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction and atrial fibrillation. Circ: Arrhythmia Electrophysiol 2011;4:733-742.

Ramirez RJ, Sah R, Liu J, Rose RA, Backx PH. Intracellular Na+ modulates synergy between Na+/Ca2+ exchanger and L-type Ca2+ current in cardiac excitation-contraction coupling during action potentials. Bas Res Cardiol 2011;106:967-977.

Rose RA. Keeping the clocks ticking as we age: changes in sinoatrial node gene expression and function in the aging heart. Exp Physiol 2011;96:1114-1115.

Rose RA. CD-NP, a chimeric natriuretic peptide for the treatment of heart failure. Curr Opin Investig Drugs 2010;11:349-356.

Rose RA, Keating A, Backx PH. Do mesenchymal stromal cells transdifferentiate into functional cardiomyocytes? Circ Res 2008;103:e120.

Rose RA, Jiang H, Wang X, Helke S, Tsoporis JN, Gong N, Keating SCJ, Parker TG, Backx PH, Keating A. Bone marrow-derived mesenchymal stromal cells express cardiac-specific markers, retain the stromal phenotype and do not become functional cardiomyocytes in vitro. Stem Cells 2008;26:2884-2892.

Cifelli C*, Rose RA*, Zhang H, Backx PH, Heximer SP. RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node. Circ Res 2008;103:527-535.

Rose RA and Giles WR. Natriuretic peptide C receptor (NPR-C) signaling in the heart and vasculature. J Physiol. 2008;586:353-366.

Rose RA, Kabir MG and Backx PH. Altered heart rate and sinoatrial node function in mice lacking the cAMP regulator phosphoinositide 3-kinase-γ. Circ Res. 2007;101:1274-1282.

Rose RA, Hatano N, Ohya S, Imaizumi Y and Giles WR. CNP activates a nonselective cation current in acutely isolated rat cardiac fibroblasts via NPR-C receptor mediated signaling. J Physiol. 2007;580:255-274.

Kerfant B-G*, Rose RA*, Sun H and Backx PH. P13Kγ regulates cardiac contractility by locally controlling cAMP levels. Trends Cardiovasc Med 2006;16:250-255.

Rose RA, Anand-Srivastava MB, Giles WR, and Bains JS. C-type natriuretic peptide inhibits L-type Ca2+ current in rat magnocellular neurosecretory cells by activating the NPR-C receptor. J Neurophysiol 2005;94:612-621.

Rose RA, Lomax AE, Kondo CS, Anand-Srivastava MB, and Giles WR. Effects of C-type natriuretic peptide on ionic currents in mouse sinoatrial node: A role for the NPR-C receptor. Am J Physiol 2004;286:H1970-H1977.

Rose RA, Lomax AE and Giles WR. Inhibition of L-type calcium current by C-type natriuretic peptide in bullfrog atrial myocytes: an NPR-C mediated effect. Am J Physiol 2003;285:H2454-H2462.

Lomax AE, Rose RA and Giles WR. Electrophysiological evidence for a gradient of G protein-gated K+ current in adult mouse atria. Br J Pharmacol. 2003;140:576-584.

Rose RA, MacDougall K, Patel A, Wilkens JL, and Walker RL. Effects of Walking on ventilatory and cardiac function in intact and cardiac impaired lobsters. Physiol Biochem Zool 2001;74:102-110.

Rosenberg HI and Rose R. Volar adhesive pads of the feathertail glider, Acrobates pygmaeus (Marsupialia; Acrobatidae). Can J Zool 1999;77:233-248.

Rose RA, Wilkens JL and Walker RL. The effects of walking on heart rate, ventilation rate, and acid-base status in the lobster Homarus americanus. J Exp Biol 1998;201:2601-2608.

Windhorst U, Kirmayer D, Soibelman F, Misri A, and Rose R. Effects of neurochemically excited group III-IV muscle afferents on motoneuron afterhyperpolarization. Neuroscience 1997;76:915-929.